DCC rabbit pAb - ES4972

DCC rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES4972-50, ES4972-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009],

Alternate Name: DCC; IGDCC1; Netrin receptor DCC; Colorectal cancer suppressor; Immunoglobulin superfamily DCC subclass member 1; Tumor suppressor protein DCC

Source: Rabbit

Applications: WB; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human DCC. AA range:441-490

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 160kD

Human Gene ID: 1630

Human SWISS Prot NO: P43146

Subcellular Location: Membrane; Single-pass type I membrane protein.

Research Use Only