Product Description

DDB1 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB0133-50, MB0133-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit.This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage.Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit.In addition, Best vitelliform mascμlar dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.The protein encoded by this gene also functions as an adaptor molecμle for the cμllin 4 (Cμl4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Monkey

Host: Mouse

Applications: WB

Alternate Names: XPE, DDBA, XAP1, XPCE, XPE-BF, UV-DDB1

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Recombinant fμll length Human DDB1.

Dilution: WB, 1:500 - 1:2000

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: This antibody detects endogenous levels of DDB1 and does not cross-react with related proteins

Molecular Weight: ~ 127 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q16531

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only