DDB1 Mouse Monoclonal Antibody - RA11085

DDB1 Mouse Monoclonal Antibody

Size: 50μL, 100μL

Catalogue Numbers: RA11085-50, RA11085-100

Citations, Manuals and MSDS Available upon request.

Background: damage specific DNA binding protein 1 (DDB1) Homo sapiens The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecul

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Applications: WB

Species Cross-Reactivity: Human; Mouse; Rat; Monkey

GeneID (Human): 1642

Protein MW (KDa): 127

SWISS: Q16531

Source: Mouse

Research Use Only