DDB2 Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA31944-50, RA31944-100
Citations, Manuals and MSDS Available upon request.
Background: damage specific DNA binding protein 2 (DDB2) Homo sapiens This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014],
Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Storage Instructions: -20°C/1 year
Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000
Applications: WB; ELISA
Species Cross-Reactivity: Human; Mouse
GeneID (Human): 1643
Protein MW (KDa): 46
SWISS: Q92466
Source: Rabbit
Research Use Only