DDR2 Monoclonal Antibody
Size: 50μL, 100μL
Catalogue Numbers: RA11087-50, RA11087-100
Citations, Manuals and MSDS Available upon request.
Background: discoidin domain receptor tyrosine kinase 2 (DDR2) Homo sapiens Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcr
Condition: Ascitic fluid containing 0.03% sodium azide, 0.5% BSA, 50% glycerol.
Storage Instructions: -20°C/1 year
Applications: WB; IHC-p; IF/ICC; ELISA
Species Cross-Reactivity: Human
GeneID (Human): 4921
SWISS: Q16832
Source: Mouse
Research Use Only