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DDX6 Polyclonal Antibody-BS90404

DDX6 Polyclonal Antibody-BS90404

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DDX6 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90404-50, BS90404-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P26196(Human) P54823(Mouse)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

All Applications: WB:1:500-1:1,000
IHC:1:50-1:100

Background: RCK, also known as DDX6 and P54, is a member of the DEAD-box RNA helicase family of proteins, all of which share common protein motifs. Found in most tissues, RCK is an unwindase that exhibits ATP-dependent RNA un-winding activity, as well as the ability to decay RNA in the 5'-3' direction. In non-malignant cells, RCK is associated with all processes of normal RNA metabolism including splicing, export and translation initiation. Mutations in the gene encoding RCK can cause the protein to be overexpressed, changing its function to that of an oncogene that positively regulates the expression of genes involved in cell growth and proliferation. It is believed that, through its unwindase activity, the main function of RCK is to downregulate mRNA expression and maintain normal transcriptional levels within the cell.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: DDX6 polyclonal antibody detects endogenous levels of DDX6 protein.

Bioworld Molecular Weight: 54 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of DDX6 on different lysates using anti-DDX6 antibody at 1/500 dilution.
Positive control:
Lane 1: Human colon
Lane 2: SH-SY-5Y
Lane 3: SiHa
Lane 4: K562, Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-DDX6 antibody. Counter stained with hematoxylin.

Alternative Name: DDX6, HLR2, RCK, ATP dependent RNA helicase DDX6, ATP dependent RNA helicase p54, DDX6, DEAD (Asp Glu Ala Asp) box polypeptide 6, DEAD box 6, DEAD box protein 6, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 6 (RNA helicase 54kD), FLJ36338, HLR2, Oncogene RCK, P54, Probable ATP-dependent RNA helicase DDX6, RCK,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodified