Product Description

Defensin α3 (S52) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS3452-50, BS3452-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P59666

Host: Rabbit

Reactivity: Human

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: Defensins are a family of microbicidal and cytotoxic peptides which are made by neutrophils and are thought to be involved in host defense. Defensins are abundant in the granules of neutrophils and are also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract and vagina. There are six α-defensins, which are known as human neutrophil peptides (HNPs) in humans. HNP-1,2,3 and 4 are found in the microbicidal granules of neutrophils; HNP-5 and HNP-6 are located in Paneth cells of the intestinal tract. HNP-1 is found in the microbicidal granules of neutrophils and probably plays a role in phagocyte-mediated host defense. HNP-1, HNP-2 and HNP-3, which comprise about 30% of the total granule protein of the neutrophil, are secreted by most normal individuals. The HNP-1 protein is encoded by the a1-defensin (DEFA1) gene. HNP-3 is encoded by the a3-defensin (DEFA3) gene.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Defensin α3 (S52) polyclonal antibody detects endogenous levels of Defensin α3 protein.

Immunogen: Synthetic peptide, corresponding to amino acids 30-70 of Human Defensin α3.

Conjugate: Unconjugated

Modification: Unmodified

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of Defensin α3 (S52) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.