Defensin α4 (D27) Polyclonal Antibody
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Catalogue Numbers: BS3497-50, BS3497-100
Sizes: 50µl, 100µl
Swiss-Prot: P12838
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: IHC
Background: Human neutrophil alpha-defensins (also designated HNPs) are small, cationic,cysteine-rich antimicrobial proteins that play important roles in innate
immunity against infectious microbes such as bacteria, fungi and enveloped viruses. Alpha-defensins are synthesized as inactive precursors and are activated by proteolytic cleavage by MMP-7. Paneth cells in small intestinal crypts secrete the alpha-defensins, which are also termed cryptidins in mice.The cryptidin-4 gene is unique among the Paneth cell alpha defensins in that it is inactive in the duodenum, but expressed at maximal levels in the distal small bowel.
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Specificity: Defensin α4 (D27) polyclonal antibody detects endogenous levels of Defensin α4 protein.
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Immunohistochemistry (IHC) analyzes of Defensin α4 (D27) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.
Bioworld Molecular Weight: ~ 11 kDa
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Alternative Name: Neutrophil defensin 4; Defensin; alpha 4; HNP-4; HP-4; DEFA4; DEF4; α-defensin 4
Immunogen: Synthetic peptide, corresponding to the N-terminus of Human Defensin α4.
Conjugate: Unconjugated
Modification: Unmodified