DEK Polyclonal Antibody-BS90405

DEK Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90405-50, BS90405-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P35659(Human)

Host: Rabbit

Reactivity: Human

Applications: WB IP

All Applications: WB:1:500-1:1,000
IP:1:50-1:100

Background: The mammalian nuclear phosphoprotein DEK is implicated in multiple cellular processes, including transcriptional regulation, mRNA processing, and chromatin remodeling, and is associated with a number of clinical autoimmune and neoplastic conditions. DEK, an abundant chromatin-associated protein, changes the topology of DNA in chromatin in vitro. Although first identified in a fusion with the CAN/Nup214 nucleoporin protein in a specific subtype of acute myelogenous leukemia, DEK is also an autoantigen in patients with Pauciarticular onset juvenile rheumatoid arthritis. Furthermore, the last 65 amino acids of DEK can partially reverse the mutation-prone phenotype of cells from patients with ataxia-telangiectasia. The human DEK gene maps to chromosome 6p22.3.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of DEK on A431 cell lysate using anti-DEK antibody at 1/500 dilution.

Bioworld Molecular Weight: 43 kDa

Specificity: DEK polyclonal antibody detects endogenous levels of DEK protein.

Alternative Name: DEK, D6S231E, Dek, DEK gene, DEK oncogene, DEK oncogene DNA binding, DEK, Protein DEK,

Immunogen: Recombinant protein corresponding to C-terminal human DEK.

Conjugate: Unconjugated

Modification: Unmodified