DeltaNp63 alpha Monoclonal Antibody - BT-MCA2761

DeltaNp63 alpha Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA2761-50, BT-MCA2761-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8.

Research Areas: Others

Target Protein: DeltaNp63 alpha

Applications: IHC, FCM

Clonality: Monoclonal

Clone ID: 2F3H6

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: DeltaNp63 alpha

Immunogen: Purified recombinant fragment of human TP63 (AA: 5-17) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 76.8kDa

UniProt Accession: Q9H3D4

Synonyms: TP63,AIS, KET, LMS, NBP, RHS, p40, p51, p63, EEC3, OFC8, p73H, p73L, SHFM4, TP53L, TP73L, p53CP, TP53CP, B(p51A), B(p51B)

GeneID: 8626

Research Use Only