Dematin (phospho Ser403) Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA24168-50, RA24168-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: dematin actin binding protein (DMTN) Homo sapiens The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding di Reactivity: Human, Mouse Host: Rabbit Applications: WB, IHC-p, IF (paraffin section), ELISA Alternate Names: EPB49, DMT, Dematin, Erythrocyte membrane protein band 4.9 Clonality: Polyclonal Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. Molecular Weight: 55 Protein Molecular Weight (kDa): 55 Storage: -20°C/1 year Human Gene ID: 2039 Human SwissProt Number: Q08495 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only