Product Description

Desmin Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66908-50, MB66908-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The cytoskeleton consists of three types of cytosolic fibers: microfilaments , intermediate filaments and microtubμles. Major types of intermediate filaments are distinguished and expressed in particμlar cell types: cytokeratins , glial fibrillary acidic protein or GFAP, desmin , vimentin and neurofilaments . GFAP and vimentin form intermediate filaments in astroglial cells and modμlate their motility and shape . In particμlar, vimentin filaments are present at early developmental stages, while GFAP filaments are characteristic of differentiated and mature brain astrocytes. Thus, GFAP is commonly used as a marker for intracranial and intraspinal tumors arising from astrocytes . Vimentin is present in sarcomas, but not carcinomas, and its expression is examined relative to other markers to distinguish between the two forms of neoplasm . Desmin is a myogenic marker expressed in early development that forms a network of filaments that extends across the myofibril and surrounds Z discs. The desmin cytoskeleton provides a connection among myofibrils, organelles and the cytoskeleton. Desmin knockout mice develop cardiomyopathy, skeletal and smooth muscle defects . In humans, desmin related myopathies might be caused by mutations in the corresponding desmin gene or in proteins with which desmin interacts, including 伪B-crystallin and synemin. Disorganized desmin filaments and the accumμlation of protein aggregates comprised predominantly of desmin characterize desmin-related myopathies .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: Desmin

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human Desmin. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of Desmin protein.

Molecular Weight: ~ 57 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P17661

Product: Mouse IgM kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only