DESP rabbit pAb - ES16958

DESP rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES16958-50, ES16958-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],

Source: Rabbit

Applications: IHC; IF

Dilution: IHC-p 1: 50-200

Reactivity: Human; Mouse

Immunogen: Synthesized peptide derived from human DESP AA range: 1546-1596

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 1832

Human SWISS Prot NO: P15924

Subcellular Location: Cell junction, desmosome. Cytoplasm, cytoskeleton. Cell membrane. Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network (PubMed:12802069). Localizes at the intercalated disk in cardiomyocytes (By similarity).

Research Use Only