DFFA Monoclonal Antibody - BT-MCA3777

DFFA Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3777-50, BT-MCA3777-100

Citations, Manuals and MSDS Available upon request.

Background: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Research Areas: Cell Biology

Target Protein: DFFA

Applications: FCM

Clonality: Monoclonal

Clone ID: 2B10C8

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: DFFA

Immunogen: Purified recombinant fragment of human DFFA (AA: 179-331) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 36.5kDa

UniProt Accession: O00273

Synonyms: DFF1, ICAD, DFF-45

GeneID: 1676

Research Use Only