Product Description

DFFB Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA24185-50, RA24185-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: DNA fragmentation factor subunit beta (DFFB) Homo sapiens Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013],

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: IHC-p, IF (paraffin section), WB

Alternate Names: DNA fragmentation factor subunit beta (EC 3.-.-.-;Caspase-activated deoxyribonuclease;CAD;Caspase-activated DNase;Caspase-activated nuclease;CPAN;DNA fragmentation factor 40 kDa subunit;DFF-40)

Clonality: Polyclonal

Dilution: IHC-p 1:50-200, WB 1:500-2000

Molecular Weight: 37

Protein Molecular Weight (kDa): 37

Storage: -20°C/1 year

Human Gene ID: 1677

Human SwissProt Number: O76075

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only