Product Description

DHB1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA31973-50, RA31973-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: hydroxysteroid 17-beta dehydrogenase 1 (HSD17B1) Homo sapiens This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight: 36

Protein Molecular Weight (kDa): 36

Storage: -20°C/1 year

Human Gene ID: 3292

Human SwissProt Number: P14061

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only