DHE3 rabbit pAb - ES16951

DHE3 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES16951-50, ES16951-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. [provided by RefSeq, Jan 2016],

Source: Rabbit

Applications: WB

Dilution: WB 1: 500-2000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human DHE3

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 2746

Human SWISS Prot NO: P00367

Subcellular Location: Mitochondrion. Endoplasmic reticulum. Mostly translocates into the mitochondria, only a small amount of the protein localizes to the endoplasmic reticulum.

Research Use Only