Product Description

Dicer Polyclonal Antibody

Catalogue Numbers: BS67544-50, BS67544-100

Sizes: 50µl, 100µl

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: Q9UPY3

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: Dicer is a member of the RNase III family that specifically cleaves double-stranded RNAs to generate microRNAs (miRNAs) . After long primary transcript pri-miRNAs are processed to stem-looped pre-miRNAs by Drosha , pre-miRNAs are transported to the cytoplasm and further processed by Dicer to produce 22-nucleotide mature miRNAs . The mature miRNA then becomes a part of the RNA-Induced Silencing Complex (RISC) and can bind to the 3' UTR of the target mRNA.

Purification and Purity: The antibody was purified by immunogen affinity chromatography.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of Dicer protein.

Extra Notes: Western blot analysis of Dicer expression in mouse testis (A), EC9706 (B), HEK293T (C), MCF7 (D) whole cell lysates.

Bioworld Molecular Weight: ~ 260 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: DICER; HERNA; KIAA0928; Endoribonuclease Dicer; Helicase with RNase motif; Helicase MOI

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Dicer. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified