DIO2 Polyclonal Antibody - E-AB-13198

DIO2 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-13198-60, E-AB-13198-120, E-AB-13198-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: DIO2

Target Synonym: 5DII; D2; Deiodinase; iodothyronine; type II; DIO2; DIOII; EC 1.97.1.10; IOD2; ITDI2; SelY; Thyroxine deiodinase; type II; TXDI2; Type 2 DI; Type 2 iodothyronine deiodinase; Type II 5' deiodinase; Type II iodothyronine deiodinase; Type-II 5''-deiodinase

Research Areas: Cancer, Metabolism, Neuroscience, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q92813

Background: The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3, 3', 5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.

Concentration: 0.9 mg/mL

Immunogen: Synthetic peptide of human DIO2

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: IHC 1:25-1:100

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only