DIO3 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA24216-50, RA24216-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: deiodinase, iodothyronine type III (DIO3) Homo sapiens The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3, 3', 5-triiodothyronine (T3) to inactive metabolites, 3, 3', 5'-triiodothyronine (RT3) and 3, 3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in pregnant uterus, placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It regulates circulating fetal thyroid hormone concentrations, and thus plays a critical role in mammalian development. Knockout mice lacking this gene exhibit abnormalities related to development and reproduction, and increased activity of this enzyme in infants with hemangiomas causes severe hypothyroidism. This protei Reactivity: Human, Mouse, Rat Host: Rabbit Applications: WB, ELISA Alternate Names: DIO3, ITDI3, TXDI3, Type III iodothyronine deiodinase, 5DIII, DIOIII, Type 3 DI, Type-III 5'-deiodinase Clonality: Polyclonal Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. Molecular Weight: 31 Protein Molecular Weight (kDa): 31 Storage: -20°C/1 year Human Gene ID: 1735 Human SwissProt Number: P55073 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only