Product Description

DMGDH Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-17889-60, E-AB-17889-120, E-AB-17889-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: DMGDH

Target Synonym: Dimethylglycine dehydrogenase; Dimethylglycine dehydrogenase; mitochondrial; Dmgdh; M2GD; ME2GLYDH; mitochondrial

Research Areas: Metabolism, Neuroscience, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human

Application: WB, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q9UI17

Background: This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. Alternative splicing results in multiple transcript variants.

Concentration: 2.1 mg/mL

Immunogen: Synthetic peptide of human DMGDH

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:500-1:2000, ELISA 1:5000-1:10000

Calculated MW: 97 kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only