DMPK Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA24240-50, RA24240-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: dystrophia myotonica protein kinase (DMPK) Homo sapiens The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5, 000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2016], Reactivity: Human, Rat, Mouse Host: Rabbit Applications: WB, ELISA Alternate Names: DMPK, DM1PK, MDPK, Myotonin-protein kinase, MT-PK, DM-kinase, DMK, DM1 protein kinase, DMPK, Myotonic dystrophy protein kinase Clonality: Polyclonal Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. Molecular Weight: 70 Protein Molecular Weight (kDa): 70 Storage: -20°C/1 year Human Gene ID: 1760 Human SwissProt Number: Q09013 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only