Product Description

DNA pol ε 2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS5700-50, BS5700-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: DNA replication, recombination and repair, all of which are necessary for genome stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. Exonucleases involved in these processes include DNA polymerases, including DNA pol δ and ε. DNA pol δ consists of two subunits-p125 which interacts directly with the sliding DNA clamp protein PCNA, and p50. DNA pol δ can be regμlated by cell cycle proteins. DNA pol ε is a mμltiple subunit enzyme, the catalytic subunit of which is encoded by the POL2 gene. The exact reactions catalyzed by DNA pol δ and ε on leading and lagging strands have not yet been elucidated.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: DNA polymerase epsilon subunit 2, DNA polymerase II subunit 2, DNA polymerase epsilon subunit B, POLE2, DPE2, DNA pol ε2, DNA pol εB, DNA pol ε B, DNA polε2, DNApolε2, DNA polεB, DNApolεB,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 144-189 of Human DNA pol ε 2.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: DNA pol ε 2 polyclonal antibody detects endogenous levels of DNA pol ε 2 protein.

Molecular Weight: ~ 60 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P56282

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only