Product Description

DNM1L Mouse Monoclonal Antibody

Sizes: 25μl, 100μl

Catalogue Numbers: MB4009-25, MB4009-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Dynamin-related protein 1 (DRP1) is a member of the dynamin superfamily of GTPases. Members of this family have diverse cellμlar functions including vesicle scission, organelle fission, viral resistance, and intracellμlar trafficking. DRP1 affects mitochondrial morphology and is important in mitochondrial and peroxisomal fission in mammalian cells. The yeast ortholog of DRP1 clusters into a spiral-shaped structure on the mitochondrial membrane at the site of fission, and this structure is likely conserved in mammalian cells. The division of the mitochondria, which is required for apoptosis, as well as normal cell growth and development is controlled, in part, by the phosphorylation of DRP1 at Ser616 by Cdk1/cyclin B and at Ser637 by protein kinase A (PKA). When phosphorylated at Ser616, DRP1 stimμlates mitochondrial fission during mitosis. Conversely, fission is inhibited when DRP1 is phosphorylated at Ser637. Dephosphorylation at Ser637 by calcineurin reverses this inhibition. In addition to phosphorylation, sumoylation of DRP1 is also an enhancer of mitochondrial fission. Balancing fission and fusion events is essential for proper mitochondrial function. Research studies have demonstrated mitochondrial defects in a variety of neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.

Category: Primary Antibody

Reactivity: Human, Dog, Rat, Monkey, Mouse

Host: Mouse

Applications: IHC, WB

Alternate Names: Dynamin-1-like protein, EC:3.6.5.5, Dnm1p/Vps1p-like protein (DVLP), Dynamin family member proline-rich carboxyl-terminal domain less (Dymple), Dynamin-like protein, Dynamin-like protein 4, Dynamin-like protein IV (HdynIV), Dynamin-related protein 1, DNM1L

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Fμll length human recombinant protein of human DNM1L(NP_036192) produced in HEK293T cell.

Dilution: WB 1:200~4000, IHC 1:150

Purification: The antibody was affinity-purified from mouse ascites fluids or tissue cμlture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IgG2b

Molecular Weight: ~ 81 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O00429

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only