DNMT3B Rabbit pAb
Sizes: 20μL, 100μL
Catalogue Numbers: A11079-20, A11079-100
Citations, Manuals and MSDS Available upon request.
Background: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
Category: Polyclonal Antibodies
Applications: WB, IHC-P, ELISA
Cross-reactivity: Mouse, Rat
Protein Weight: 96kDa
Observed Molecular Weight: 96kDa/110kDa
Immunogen: Recombinant protein (or fragment)
Species: Human
GeneID: 1789
SWISS: Q9UBC3
Alternate Names: ICF; ICF1; FSHD4; M.HsaIIIB; DNMT3B
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilutions: WB, 1:500 - 1:1000 IHC-P, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Research Areas: Epigenetics Nuclear Signaling, Epigenetic writers and erasers of core Histones.
NCBI Alias: DNMT3B
Research Use Only