DOC-1 rabbit pAb - ES2190

DOC-1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES2190-50, ES2190-100

Citations, Manuals and MSDS Available upon request.

Background: cyclin dependent kinase 2 associated protein 1 (CDK2AP1) Homo sapiens The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],

Alternate Name: CDK2AP1; CDKAP1; DOC1; Cyclin-dependent kinase 2-associated protein 1; CDK2-associated protein 1; Deleted in oral cancer 1; DOC-1; Putative oral cancer suppressor

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human CDKAP1. AA range:51-100

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 20kD

Human Gene ID: 8099

Human SWISS Prot NO: O14519

Subcellular Location: nucleus, perinuclear region of cytoplasm,

Research Use Only