Product Description

DOCK8 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10845-50, MB10845-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q8NF50

Host: Rabbit

Reactivity: Human

Applications: WB,ICC/IF

All Applications: WB: 1/500-1/1000 IF: 1/50-1/200

Background: Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC . Required for CD4+ T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780).

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of DOCK8 in RamosLysates using DOCK8 antibody.

Bioworld Molecular Weight: Calculated MW: 239 kDa; Observed MW: 239 kDa

Specificity: IgG

Alternative Name: MRD2; ZIR8; HEL-205

Immunogen: Recombinant protein of human DOCK8

Conjugate: Unconjugated

Modification: Unmodified