Dok-4 rabbit pAb - ES2193

Dok-4 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES2193-50, ES2193-100

Citations, Manuals and MSDS Available upon request.

Background: domain:PTB domain mediates receptor interaction., function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells., PTM:Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation., similarity:Belongs to the DOK family. Type B subfamily., similarity:Contains 1 IRS-type PTB domain., similarity:Contains 1 PH domain., subunit:Interacts with RET and TEK/TIE2. Interaction with RET is mediated through the PTB domain and requires phosphorylation of RET 'Tyr-1062'., tissue specificity:Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells.,

Alternate Name: DOK4; Docking protein 4; Downstream of tyrosine kinase 4; Insulin receptor substrate 5; IRS-5; IRS5

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human DOK4. AA range:11-60

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 37kD

Human Gene ID: 55715

Human SWISS Prot NO: Q8TEW6

Subcellular Location: intracellular,

Research Use Only