DOK1 Polyclonal Antibody - E-AB-10290

DOK1 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-10290-60, E-AB-10290-120, E-AB-10290-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: DOK1

Target Synonym: Docking protein 1 62kD; Docking protein 1; DOK 1; DOK1; DOK1; Downstream of tyrosine kinase 1; p62(dok); P62DOK; pp62

Research Areas: Cancer, Cardiovascular, Metabolism, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: WB, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q99704

Background: The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Concentration: 0.5 mg/mL

Immunogen: Recombinant protein of human DOK1

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000

Calculated MW: 52kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only