Product Description

DOK7 Polyclonal Antibody

Catalogue Numbers: BS62278-50, BS62278-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q18PE1

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, IHC, IF

All Applications: WB:1:500~1:1000 IHC:1:50~1:200 IF:1:50~1:200

Background: The downstream of kinase family (Dok1-7) are members of a class of “docking” proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Based on their similarities, the Dok family of proteins can be divided into three subgroups: Dok-1/2/3, Dok-4/5/6 and Dok-7. Through its interaction with musclespecific receptor kinase (MuSK), Dok-7 is crucial for neuromuscular synaptogenesis and for MuSK activation. Mice lacking Dok-7 do not form neuromuscular synapses nor acetylcholine receptor clusters. Mutations in the Dok-7 gene can cause congenital myasthenic syndromes (CMA)-recessively inherited disorders characterized by muscle weakness.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: DOK7 polyclonal antibody detects endogenous levels of DOK7 protein.

Extra Notes: Western blot (WB) analysis of DOK7 polyclonal antibody at 1:500 dilution
LaneA:HEK293T whole cell lysate
LaneB:The Brain tissue lysate of Mouse
LaneC:The Brain tissue lysate of Rat

Bioworld Molecular Weight: ~ 53 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Protein Dok-7; Downstream of tyrosine kinase 7; DOK7; C4orf25

Immunogen: Synthetic peptide, corresponding to Human DOK7.

Conjugate: Unconjugated

Modification: Unmodified