DOPA Decarboxylase Polyclonal Antibody-BS90425

DOPA Decarboxylase Polyclonal Antibody Sizes: 50µl, 100µl Catalogue Numbers: BS90425-50, BS90425-100 Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Swiss-Prot: P20711(Human) O88533(Mouse) P14173(Rat) Host: Rabbit Reactivity: Human, Mouse, Rat Applications: WB, IHC All Applications: WB:1:500-1:1,000 IHC:1:50-1:200 Background: DOPA decarboxylase (DDC), also designated aromatic-L-amino-acid decarboxylase (AADC) belongs to the group II decarboxylase family of proteins. DDC, which can form a homodimer, is an important protein in the catecholamine biosynthesis pathway. DDC acts as a catalyst in the decarboxylation of L-5-hydroxytryptophan to serotonin, L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-tryptophan to tryptamine. Defects in the gene encoding for DDC may cause the autosomal recessive disorder AADC deficiency. AADC deficiency is an early onset inborn error in neurotransmitter metabolism which can lead to catecholamine and serotonin deficiency. This causes poor feeding, psychomotor and developmental delays, lethargy, ptosis, gastrointestinal disturbances and hypothermia.  Purification and Purity: ProA affinity purified Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Specificity: DOPA Decarboxylase polyclonal antibody detects endogenous levels of DOPA Decarboxylase protein. Bioworld Molecular Weight: 53 kDa Note: For research use only, not for use in diagnostic procedure. Extra Notes: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-DOPA Decarboxylase antibody. Counter stained with hematoxylin., Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-DOPA Decarboxylase antibody. Counter stained with hematoxylin. Alternative Name: AADC, DDC, AADC, Aromatic L Amino Acid Decarboxylase, Aromatic-L-amino-acid decarboxylase, Ddc, DDC, DOPA decarboxylase (aromatic L-amino acid decarboxylase), DOPA decarboxylase, Immunogen: Recombinant protein Conjugate: Unconjugated Modification: Unmodified