DPM1 Polyclonal Antibody - E-AB-62982

DPM1 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-62982-60, E-AB-62982-120, E-AB-62982-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: DPM1

Target Synonym: DPM1; CDGIE; MPDS

Research Areas: Tags and Cell Markers

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: IF

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: O60762

Background: Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human DPM1 (NP_003850.1).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification Method: Affinity purification

Dilution: IF 1:50-1:200

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only