Product Description

DSCR1 Polyclonal Antibody

Catalogue Numbers: BS62261-50, BS62261-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P53805

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB:1:500~1:1000

Background: Calcipressin-1, also known as DSCR1 (Down syndrome critical region 1), Adapt78, MCIP1 (myocyte-enriched calcineurin-interacting protein 1) or regulator of calcineurin 1, is a 252 amino acid protein that belongs to the RCAN family and exists as four alternatively spliced isoforms. Abundantly expressed in skeletal muscle, brain and heart, DSCR 1 is thought to influence cardiac and nervous system development. Overexpression of DSCR1 may play a role in the pathogenesis of Down syndrome. DSCR1 interacts with Raf-1 and has been observed to inhibit calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. The gene encoding DSCR 1 maps to human chromosome 21, which which houses approximately 300 genes and comprises nearly 1.5% of the human genome. Chromosome 21-associated disorders include Alzheimer's disease, amyotrophic lateral sclerosis and, most notably, Down syndrome (also known as trisomy 21).

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: DSCR1 polyclonal antibody detects endogenous levels of DSCR1 protein.

Extra Notes: Western blot (WB) analysis of DSCR1 polyclonal antibody at 1:500 dilution
LaneA:NIH3T3 whole cell lysate
LaneB:CT26 whole cell lysate
LaneC:H9C2 whole cell lysate
LaneD:PC12 whole cell lysate

Bioworld Molecular Weight: ~ 23 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Calcipressin 1; Calcipressin1; Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1; RCAN1; ADAPT78; CSP1; DSC1; DSCR1

Immunogen: Synthetic peptide, corresponding to Human DSCR1.

Conjugate: Unconjugated

Modification: Unmodified