Dvl-2 rabbit pAb - ES5034

Dvl-2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES5034-50, ES5034-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008],

Alternate Name: DVL2; Segment polarity protein dishevelled homolog DVL-2; Dishevelled-2; DSH homolog 2

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: Synthesized peptide derived from Dvl-2 . at AA range: 670-750

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 80kD

Human Gene ID: 1856

Human SWISS Prot NO: O14641

Subcellular Location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Cytoplasmic vesicle. Nucleus. Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Interaction with FOXK1 and FOXK2 induces nuclear translocation (PubMed:25805136).

Research Use Only