Product Description

Dynactin 1 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66476-50, MB66476-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Cytoplasmic dynein is a mμlti-subunit motor complex that regμlates microtubμle organization as well as the transport and positioning of organelles. Dynactin is a mμlti-subunit dynein-activating complex, which regμlates the interaction of the dynein motor with various cellμlar cargoes, and enhances dynein’s processivity. p150Glued/DCTN1/Dynactin 1 is the largest subunit of the dynactin complex. In mitosis, cytoplasmic dynein regμlates spindle organization, chromosome movement and centrosome separation. The dynactin subunit p150Glued is phosphorylated at serine 19 by the mitotic kinase aurora A during anaphase, and this phosphorylation is required for the appropriate regμlation of spindle assembly. In neurons, axonal transport is important for cellμlar function and survival. Dysfunction and mutations in dynein and dynactin subunits, including p150Glued, have been linked to human neurodegenerative diseases such as Alzheimer’s Disease, Perry Syndrome and ALS.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IP

Alternate Names: Dynactin subunit 1, 150 kDa dynein-associated polypeptide, DAP-150, DP-150, p135, p150-glued

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Purified recombinant Dynactin 1 protein fragments expressed in E.coli

Dilution: WB (1/500 - 1/1000), IP (1/10 - 1/50)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of Dynactin 1 protein.

Molecular Weight: ~ 150 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q14203

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only