Dynactin 1 (N-term) Mouse Monoclonal Antibody - RA11107

Dynactin 1 (N-term) Mouse Monoclonal Antibody

Size: 50μL, 100μL

Catalogue Numbers: RA11107-50, RA11107-100

Citations, Manuals and MSDS Available upon request.

Background: dynactin subunit 1 (DCTN1) Homo sapiens This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA) . [

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Applications: WB; IP

Species Cross-Reactivity: Human

GeneID (Human): 1639

Protein MW (KDa): 150

SWISS: Q14203

Source: Mouse

Research Use Only