Product Description

Dynactin 1 (N-term) Mouse Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA11107-50, RA11107-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: dynactin subunit 1 (DCTN1) Homo sapiens This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [

Reactivity: Human

Host: Mouse

Applications: WB, IP

Alternate Names: 150 kDa dynein associated polypeptide, 150 kDa dynein-associated polypeptide, DAP 150, DAP-150, DAP150, DCTN 1, DCTN1, DCTN1_HUMAN, DP 150, DP-150, DP150, Dynactin 1 (p150 Glued (Drosophila) homolog), dynactin 1 (p150 glued homolog Drosophila), Dynactin 1, Dynactin subunit 1, Dynactin1, HMN7B, p135, p150 Glued (Drosophila) homolog, p150 glued, p150 glued homolog, p150(GLUED) DROSOPHILA HOMOLOG OF, p150-glued, p150glued.

Clonality: Monoclonal

Dilution: wb 1:500

Storage: -20°C/1 year

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Human Gene ID: 1639

Protein Molecular Weight（KDa): 150

Molecular Weight: 150

Research Use Only