Dynein IC1 rabbit pAb - ES5529

Dynein IC1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES5529-50, ES5529-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

Alternate Name: DNAI1; Dynein intermediate chain 1; axonemal; Axonemal dynein intermediate chain 1

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human DNAI1. AA range:211-260

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 79kD

Human Gene ID: 27019

Human SWISS Prot NO: Q9UI46

Subcellular Location: Dynein axonemal particle. Cytoplasm, cytoskeleton, cilium axoneme.

Research Use Only