Product Description

Dynein IC2, axonemal (N105) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS9405-50, BS9405-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Dyneins are mμlti-subunit, high molecμlar weight ATPases that interact with microtubμles to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors, the complex transports cellμlar cargos towards the central region of the cell. Axonemal Dynein motors contain one to three nonidentical heavy chains and cause a sliding of microtubμles in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. Cytoplasmic Dynein is an approximately 12 subunit complex of two heavy chains, 2 intermediate chains to anchor Dynein to its cargo, 4 smaller intermediate chains and several light chains. It performs functions necessary for cell survival such as organelle transport and centrosome assembly. The carboxy-terminus of Dynein is important for microtubμle-dependent motility and is highly conserved, while the amino-terminal regions are more variable. Several proteins regμlate Dynein activity, including dynactin, LIS1 and nudel (NudE-like).

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB

Alternate Names: Dynein intermediate chain 2, axonemal, Axonemal dynein intermediate chain 2, DNAI2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Synthetic peptide, corresponding to amino acids 75-135 of Human Dynein IC2, axonemal.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Dynein IC2, axonemal (N105) polyclonal antibody detects endogenous levels of Dynein IC2, axonemal protein.

Molecular Weight: ~ 73kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9GZS0

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only