Product Description

Dystrophin Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90437-50, BS90437-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P11532(Human) P11531(Mouse) P11530(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

All Applications: WB:1:1,000
IHC:1:50-1:200

Background: Dystrophin-glycoprotein complex (DGC) connects the F-Actin cytoskeleton on the inner surface of muscle fibers to the surrounding extracellular matrix, through the cell membrane interface. A deficiency in this protein contributes to Duchenne (DMD) and Becker (BMD) muscular dystrophies. The human dystrophin gene measures 2.4 megabases, has more than 80 exons, produces a 14 kb mRNA and contains at least eight independent tissue-specific promoters and two poly A sites. The dystrophin mRNA can undergo differential splicing and produce a range of transcripts that encode a large set of proteins. Dystrophin represents approximately 0.002% of total striated muscle protein and localizes to triadic junctions in skeletal muscle, where it is thought to influence calcium ion homeostasis and force transmission.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Dystrophin polyclonal antibody detects endogenous levels of Dystrophin protein.

Bioworld Molecular Weight: 427 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue using anti-Dystrophin antibody. Counter stained with hematoxylin., Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-Dystrophin antibody. Counter stained with hematoxylin.

Alternative Name: DMD, BMD, CMD3B, DMD, DMD, Duchenne muscular dystrophy protein, Dystrophin, Muscular dystrophy Duchenne and Becker types,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified