Product Description

E-cadherin Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA11118-50, RA11118-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: cadherin 1 (CDH1) Homo sapiens This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015],

Reactivity: Human, Mouse, Monkey

Host: Mouse

Applications: WB, ELISA

Alternate Names: CDH1, CDHE, UVO, Cadherin-1, CAM 120/80, Epithelial cadherin, E-cadherin, Uvomorulin, CD antigen CD324

Clonality: Monoclonal

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Storage: -20°C/1 year

Condition: Ascitic fluid containing 0.03% sodium azide, 0.5% BSA, 50% glycerol.

Human Gene ID: 999

Protein Molecular Weight（KDa): 125-130

Molecular Weight: 125-130

Research Use Only