E-cadherin Polyclonal Antibody - RA20722

E-cadherin Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA20722-50, RA20722-100

Citations, Manuals and MSDS Available upon request.

Background: cadherin 1 (CDH1) Homo sapiens This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015],

Condition: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB: 1:1000 IHC: 1:500-1000

Alternative Names: CDH1; CDHE; UVO; Cadherin-1; CAM 120/80; Epithelial cadherin; E-cadherin; Uvomorulin; CD324; YM3353

Applications: WB; IHC-p; IF (paraffin section)

Species Cross-Reactivity: Human

GeneID (Human): 999

Protein MW (KDa): 125-130

SWISS: P12830

Source: Rabbit

Research Use Only