Product Description

E-Cadherin (R868) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1098-50, BS1098-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Cadherins are members of a mμltigene family of single chain glycoprotein receptors mediating calcium dependent cell-cell adhesion. They play an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. Cadherins are expressed in a tissue specific manner and and are required for assembly of cells into solid tissue. Individual cadherin molecμles are known to co-operate with each other to form a linear cell adhesion zipper. In adhesion junctions cadherins are bound to beta and gamma catenins which in turn bind to alpha catenin, an actin binding protein. Cadherins play an important part in tumor invasion and metastasis.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF, IP

Alternate Names: Cadherin-1, Cadherin1, Cadherin 1, CAM 120/80, Epithelial cadherin, E-cadherin, Uvomorμlin, CD324, CDH1, CDHE, UVO

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 840-880 of Human E-cadherin.

Dilution: WB: 1:500~1:1000
IHC/IF: 1:50~1:200
IP: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: E-cadherin (R868) polyclonal antibody detects endogenous levels of E-cadherin protein.

Molecular Weight: ~ 98, 130 kDa

Pathway: Neuronal and Glial Cell Marker Atlas, Contribution of ECM and Cytoskeletal Factors to EMT, Contribution of Soluble Factors to EMT, Adherens Junction signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P12830

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only