E2F-1 Mouse Monoclonal Antibody - RA11111

E2F-1 Mouse Monoclonal Antibody

Size: 50μL, 100μL

Catalogue Numbers: RA11111-50, RA11111-100

Citations, Manuals and MSDS Available upon request.

Background: E2F transcription factor 1 (E2F1) Homo sapiens The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can media

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Applications: WB; IF/ICC; IP

Species Cross-Reactivity: Human; Rat

GeneID (Human): 1869

Protein MW (KDa): 70

SWISS: Q01094

Source: Mouse

Research Use Only