Product Description

E2F-2 (Acetyl Lys122) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA24389-50, RA24389-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: function:Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F-2 binds specifically to RB1 protein, in a cell-cycle dependent manner., PTM:Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase., similarity:Belongs to the E2F/DP family., subunit:Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F-2 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle, RB1 becomes phosphorylated in mid-to-late G1 phase, detaches from the DRTF1/E2F complex, rendering E2F transcriptionally active. Viral oncoproteins, notably E1A, T-antigen and HPV E7, are capable of sequestering RB protein, thus releasing the active complex. Binds EAPP., tissue specificity:Highest level of expression is found in placenta, low levels are found in lung. Found as well in many immortalized cell lines derived from tumor samples.,

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Alternate Names: Transcription factor E2F2 (E2F-2)

Clonality: Polyclonal

Dilution: WB 1:1000-2000 ELISA 1:5000-20000

Molecular Weight: 48

Protein Molecular Weight (kDa): 48

Storage: -20°C/1 year

Human Gene ID: 1870

Human SwissProt Number: Q14209

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only