E2F4 Polyclonal Antibody - E-AB-12375

E2F4 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-12375-60, E-AB-12375-120, E-AB-12375-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: E2F4

Target Synonym: E2F 4; E2F transcription factor 4; E2F transcription factor 4 p107/p130 binding; E2F-4; E2F4; E2F4; p107/p130 binding protein; Transcription factor E2F 4; Transcription factor E2F4

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Stem Cells

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse

Application: IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q16254

Background: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two.

Concentration: 0.5 mg/mL

Immunogen: Synthetic peptide of human E2F4

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: IHC 1:50-1:200

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only