Product Description

E4BP4 (E65) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2076-50, BS2076-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: E4BP4, also known as NFIL3, functions as a transcriptional repressor and is a member of the basic leucine zipper (bZIP) transcription factor family. E4BP4 binds with high specificity to the E4 ATF, which is a DNA sequence traditionally targeted by the ATF/CREB family of transcription factors. A 65 amino acid segment located in the carboxy-terminus of E4BP4 interacts specifically with the TBP binding protein Dr1. In the suprachiasmatic nucleus, circadian center and liver, E4BP4 competes with PAR proteins for DNA binding via a reciprocating mechanism. The phase expression of E4BP4 correlates with the circadian cycle and represses transcription of genes otherwise activated by PAR transcription regμlators. E4BP4 also plays an important role in an IL-3-mediated signaling pathway that is responsible for the survival of B cell progenitors. The gene encoding human E4BP4 maps to chromosome 9q22.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: E4 promoter binding protein 4, E4 promoter-binding protein 4, E4BP 4, E4BP4, E4BP4 protein, IL3BP 1, IL3BP1, Interleukin 3 binding protein 1, Interleukin 3 promoter transcriptional activator, Interleukin-3 promoter transcriptional activator, Interleukin-3-binding protein 1, NFIL 3, NFIL 3A, NFIL3, NFIL3, NFIL3A, Nuclear factor interleukin 3 regμlated, Nuclear factor interleukin-3-regμlated protein, Transcriptional activator NF IL3A, Transcriptional activator NF-IL3A

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 32-86 of Human E4BP4.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: E4BP4 (E65) polyclonal antibody detects endogenous levels of E4BP4protein.

Molecular Weight: ~ 60 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q16649

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only