EGFR Mouse mAb - EM1134

EGFR Mouse mAb

Sizes: 50μL, 100μL

Catalogue Numbers: EM1134-50, EM1134-100

Citations, Manuals and MSDS Available upon request.

Background: The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades.

Alternate Name: Epidermal Growth Factor Receptor ; ErbB-1; ErbB1; ER1; ERB-B1; MENA; HER1; Erythroblastic Leukemia Viral (v-Erb-B)oncogene Homolog, Avian; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1

Source: Mouse

Applications: WB, IHC, IF, IP

Dilution: WB 1:1, 000-3, 000 IP 1:200 IF 1:100-200

Reactivity: Human

Immunogen: Synthetic Peptide

Storage and Stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality: Monoclonal

Isotype: IgG1

Concentration: 1mg/mL

Observed Band (KD): 170kDa

Human Gene ID: 1956

Human SWISS Prot NO: P00533

Research Use Only