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EGR2 Polyclonal Antibody-BS90452

EGR2 Polyclonal Antibody-BS90452

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EGR2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90452-50, BS90452-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P11161(Human)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, FC

All Applications: WB:1:500-1:1,000
FC:1:50-1:100

Background: The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Binds to two specific DNA sites located in the promoter region of HOXA4. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: EGR2 polyclonal antibody detects endogenous levels of EGR2 protein.

Bioworld Molecular Weight: 50 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of EGR2 on MCF-7 and SH-SY-5Y cell lysates using anti-EGR2 at 1/500 dilution., Flow cytometric analysis of SH-SY-5Y cells with EGR2 antibody at 1/50 dilution (Fuchsia) compared with an unlabelled control (cells without incubation with primary antibody; Yellow). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.

Alternative Name: EGR-2, EGR2, KROX20, AT591, CMT1D, CMT4E, DKFZp686J1957, E3 SUMO-protein ligase EGR2, Early growth response 2, Early growth response protein 2, EGR-2, egr2, EGR2, FLJ14547, KROX 20 Drosophila homolog, Krox 20 homolog Drosophila, KROX-20, Drosophila, homolog (early growth response-2), KROX20, Krox20 protein, Zinc finger protein Krox-20,

Conjugate: Unconjugated

Modification: Unmodified