eIF3L Polyclonal Antibody - BT-AP02893

eIF3L Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP02893-20, BT-AP02893-50, BT-AP02893-100

Citations, Manuals and MSDS Available upon request.

Background: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: EIF3L

Applications: WB, IF, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: eIF3L Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 66727

UniProt Accession: Human: Q9Y262; Mouse: Q8QZY1

Synonyms: EIF3L; EIF3EIP; EIF3S6IP; HSPC021; HSPC025; MSTP005; Eukaryotic translation initiation factor 3 subunit L; eIF3l; Eukaryotic translation initiation factor 3 subunit 6-interacting protein; Eukaryotic t

GeneID: Human: 51386; Mouse: 223691

Research Use Only