Product Description

EIF4G1 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-61769-60, E-AB-61769-120, E-AB-61769-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: EIF4G1

Target Synonym: EIF4G1; EIF-4G1; EIF4F; EIF4G; EIF4GI; P220; PARK18

Research Areas: Cancer,Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human

Application: WB, IHC

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q04637

Background: The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.

Concentration: 1 mg/mL

Immunogen: A synthetic peptide of human EIF4G1

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Calculated MW: 154kDa/158kDa/166kDa/171kDa/175kDa/176kDa

Observed MW: 220KDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only